検索結果

Search Results for " cholesterol biosynthesis "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T14362	AY 9944		Others
	AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM). At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomera...		Others
T26296	Triparanol	MER-29,NSC 65345,NSC-65345,NSC65345	Apoptosis , Hedgehog/Smoothened
	Triparanol (NSC-65345) interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling. Triparan...		Apoptosis , Hedgehog/Smoothened
T35973	Cholesterol-5α,6α-epoxide	Epoxycholesterol,5α,6α-epoxy Cholestanol,NSC 18176	Others
	Cholesterol-5α,6α-epoxide (Epoxycholesterol) is the metabolite of cholesterol produced by oxidation. Cholesterol-5α,6α-epoxide induces triacylglycerol biosynthesis by binding to LXRβ following tamoxifen and PBPE applicat...		Others
T12092	Monacolin J	Antibiotic MB 530A,Lovastatin diol lactone	HMG-CoA Reductase , Autophagy
	Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor.		HMG-CoA Reductase , Autophagy
T25285	Dalvastatin	RG-12561,RG 12561,RG12561	HMG-CoA Reductase
	Dalvastatin (RG-12561) is an orally available inhibitor of HMG-CoA reductase and cholesterol-lowering synthesis.Dalvastatin competitively inhibits rat hepatic HMG-CoA reductase with an IC50 value of 3.4 nmol / l. Dalvast...		HMG-CoA Reductase
T15184	E 2012		Gamma-secretase
	E2012 is a γ-secretase modulator (GSM). E2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induc...		Gamma-secretase
T1676	Rosuvastatin	ZD 4522	Potassium Channel , HMG-CoA Reductase , Autophagy
	Rosuvastatin (ZD 4522) is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting...		Potassium Channel , HMG-CoA Reductase , Autophagy
T4039	BIBB 515		Others
	BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. 2, 3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of...		Others
T15710	Lapaquistat	T-91485	Others
	Lapaquistat is a cholesterol biosynthesis inhibitor and is the active metabolite of TAK-475. Lapaquistat can reduce statin-induced myotoxicity in lipid-lowering therapy.		Others
T20999	1-(2,3-Dichlorphenyl)-piperazine	DCPP	Others
	1-(2,3-Dichlorphenyl)-piperazine (DCPP) is a potent DHCR7 inhibitor. DHCR7 is the last enzyme in cholesterol biosynthesis.		Others
T28142	NCX-6560	NCX6560
	NCX-6560 is a novel NO-releasing derivative of atorvastatin, with those of atorvastatin. NCX-6560 inhibits cholesterol biosynthesis in rat smooth muscle cells with an IC50 of 1.9 μM.
T38088	28-Deoxybetulin methyleneamine
	28-Deoxybetulin methyleneamine is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin .1It has been used in the synthesis of triterpene derivatives with antiviral activity. 1.Nitz,...
T35321	Zymostenol	delta(8)-Cholestenol,5a-Cholest-8-en-3b-ol,Δ8-Cholesterol	Endogenous Metabolite , ROR
	Zymostenol (5a-Cholest-8-en-3b-ol) is a RORγ agonist with an EC50 of 1 μM.Zymostenol is a late stage precursor of cholesterol biosynthesis.		Endogenous Metabolite , ROR
T35589	Geranyl pyrophosphate triammonium
	Geranyl pyrophosphate is an intermediate in the mevalonate pathway. It is formed from dimethylallyl pyrophosphate and isopentenyl pyrophosphate by geranyl pyrophosphate synthase. Geranyl pyrophosphate is used in the bios...
T71133	Azacosterol hydrochloride
	Azacosterol is a diaza derivative of cholesterol which acts as a hypocholesteremic agent by blocking delta-24-reductase causing accumulation of desmosterol. Azacosterol acts as an inhibitor of 24-dehydrocholesterol reduc...
T74147	Larsucosterol (trimethylamine)
	Larsucosterol (DUR-928) trimethylamine, a metabolite of cholesterol, functions as a powerful liver X receptor (LXR) antagonist, effectively reducing lipogenesis and inhibiting cholesterol biosynthesis. It achieves this b...
T37039	Betulinic Aldehyde oxime
	Betulinic aldehyde oxime is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin .1It is active againstE. aerogenes,E. coli,E. faecalis,P. aeruginosa,S. aureus, andC. albicans, as w...
T35686	3-Acetyl Betulinaldehyde
	3-Acetyl betulinaldehyde is a triterpene and derivative of the cholesterol biosynthesis inhibitor betulin that has been found inA. japonica.1It is an intermediate in the synthesis of 3-acetylbetulinic acid, as well as va...
T36318	28-Acetylbetulin
	28-Acetylbetulin is a lupane triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin that has been found inM. chiapensisand has anti-inflammatory and anticancer activities.1,2It inhibits LPS-induced...
T68219	Peraclopone
	Peraclopone is a hypolidemic drug. It is an inhibitor of 7-Dehydrocholesterol reductase. Peraclopone potently inhibits the final step in cholesterol biosynthesis. Feeding this agent to rats leads to a rapid replacement o...
T69244	Betulonaldehyde
	Betulonaldehyde is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin that has been found in Betula. It is active against P. falciparum (IC50 = 3.36 µg/ml) and cytotoxic to NCI H1...
T78081	Farnesyl Pyrophosphate ammonium	Farnesyl diphosphate ammonium
	Farnesyl Pyrophosphate Ammonium Salt, a 15-carbon isoprenoid derived from the mevalonate (MVA) pathway, functions as a TRPM2 (TRP Channel) agonist, facilitating the opening of TRPM2 channels for ion influx. It serves as ...
T70856	3-Oxobetulin Acetate
	3-Oxobetulin acetate is a derivative of the cholesterol biosynthesis inhibitor betulin. It inhibits the growth of P388 murine lymphocytic leukemia cells (EC50 = 0.12 µg/ml), as well as human MCF-7 breast, SF-268 CNS, H46...
T73755	Farnesyl pyrophosphate
	Farnesyl pyrophosphate (Farnesyl diphosphate), a 15-carbon isoprenoid derived from the mevalonate (MVA) pathway, acts as a metabolic intermediary. It serves as a TRPM2 (TRP Channel) agonist, facilitating the opening of T...
T69395	Nicotinamide-d4
	Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized i...

Compounds

Synonym: MER-29,NSC 65345,NSC-65345,NSC65345

Target: Apoptosis, Hedgehog/Smoothened

Cholesterol-5α,6α-epoxide

T35973

Synonym: Epoxycholesterol,5α,6α-epoxy Cholestanol,NSC 18176

Target: Others

Monacolin J

T12092

Synonym: Antibiotic MB 530A,Lovastatin diol lactone

Target: HMG-CoA Reductase, Autophagy

Dalvastatin

T25285

Synonym: RG-12561,RG 12561,RG12561

Target: HMG-CoA Reductase

E 2012

T15184

Synonym:

Target: Gamma-secretase

Rosuvastatin

T1676

Synonym: ZD 4522

Target: Potassium Channel, HMG-CoA Reductase, Autophagy

1-(2,3-Dichlorphenyl)-piperazine

28-Deoxybetulin methyleneamine

Synonym: delta(8)-Cholestenol,5a-Cholest-8-en-3b-ol,Δ8-Cholesterol

Target: Endogenous Metabolite, ROR

Geranyl pyrophosphate triammonium

T35589

Synonym:

Target:

Azacosterol hydrochloride

T71133

Synonym:

Target:

Larsucosterol (trimethylamine)

T74147

Synonym:

Target:

Betulinic Aldehyde oxime

T37039

Synonym:

Target:

3-Acetyl Betulinaldehyde

Farnesyl Pyrophosphate ammonium

T78081

Synonym: Farnesyl diphosphate ammonium

Farnesyl pyrophosphate

カタログ番号	製品名	別名	ターゲット
TN1576	Diallyl disulfide		IL Receptor , NOS , NF-κB
	Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.		IL Receptor , NOS , NF-κB
TN6715	7-Ketocholesterol		Others
	7-Ketocholesterol is a metabolite of Cholesterol		Others
T19711	Desmosterol	Desmesterol,24-Dehydrocholesterol	Endogenous Metabolite
	Desmosterol (24-Dehydrocholesterol) is a cholesterol biosynthesis intermediate that inhibits macrophage inflammatory vesicle activation and prevents vascular inflammation and atherosclerosis.		Endogenous Metabolite
T4923	7-Dehydrocholesterol	Provitamin D3,7-DHC	Endogenous Metabolite
	7-Dehydrocholesterol (Provitamin D3) down-regulates cholesterol biosynthesis in cultured Smith-Lemi-Opitz syndrome skin fibroblasts.		Endogenous Metabolite
T4717	25-Hydroxycholesterol		Others , Endogenous Metabolite , HMG-CoA Reductase
	25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regu...		Others , Endogenous Metabolite , HMG-CoA Reductase
T41054	γ-Glutamyl-S-allylcysteine	L-γ-Glutamyl-(S)-Allyl-Cysteine	Antioxidant
	γ-Glutamyl-S-allylcysteine (L-γ-Glutamyl-(S)-Allyl-Cysteine) is a γ-glutamyl peptide extracted from Allium sativum L. γ-Glutamyl-S-allylcysteine possesses anti-glycation and antioxidant activities, and can inhibit the ch...		Antioxidant
T1664	Meglutol	Dicrotalic acid,3-Hydroxy-3-methylglutaric acid	Endogenous Metabolite , HMG-CoA Reductase , Autophagy
	Meglutol (3-Hydroxy-3-methylglutaric acid) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conve...		Endogenous Metabolite , HMG-CoA Reductase , Autophagy
T73808	Zymosterol
	Zymosterol, a metabolite in cholesterol biosynthesis and precursor to cholesterol, predominantly resides in the plasma membrane and circulates within the cell [1] [2].
TN1655	Ganoderal A		Others
	The oxygenated sterols( 26-oxygenosterols ganoderol A, ganoderol B, ganoderal A, and ganoderic acid Y) from G. lucidum can inhibit cholesterol biosynthesis via conversion of acetate or mevalonate as a precursor of choles...		Others
T83158	Agistatin D
	Agistatin D, a pyranacetal derived from Fusarium sp., inhibits cholesterol biosynthesis [1].
TN1060	Ganoderol A		Others
	Ganoderol A has significant anti-inflammatory activity and protection against UVA damage. it has an inhibitory effect on angiotensin converting enzyme activity and cholesterol biosynthesis.		Others
T83157	Agistatin E
	Agistatin E, a pyranacetal derived from Fusarium species, impedes cholesterol biosynthesis [1].

天然物製品

Diallyl disulfide

TN1576

Synonym:

Target: IL Receptor, NOS, NF-κB

Synonym: Desmesterol,24-Dehydrocholesterol

Target: Endogenous Metabolite

7-Dehydrocholesterol

T4923

Synonym: Provitamin D3,7-DHC

Target: Endogenous Metabolite

25-Hydroxycholesterol

T4717

Synonym:

Target: Others, Endogenous Metabolite, HMG-CoA Reductase

γ-Glutamyl-S-allylcysteine

T41054

Synonym: L-γ-Glutamyl-(S)-Allyl-Cysteine

Target: Antioxidant

Meglutol

T1664

Synonym: Dicrotalic acid,3-Hydroxy-3-methylglutaric acid

Target: Endogenous Metabolite, HMG-CoA Reductase, Autophagy

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-02316	YJEFN3 Protein, Human, Recombinant	Human	E. coli
	May accelerate cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. May orchestrate hematopoietic stem and progenitor cell emergence from the hemogenic endotheli...
TMPH-01603	Lanosterol synthase/LSS Protein, Human, Recombinant (His)	Human	E. coli
	Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens prote...
TMPY-04767	PMVK Protein, Human, Recombinant (His)	Human	E. coli
	PMVK is a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level a...
TMPH-03128	TSPO Protein, Pig, Recombinant (His & Myc & SUMO)	Sus scrofa (Pig)	E. coli
	Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynt...
TMPH-01535	INSIG2 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol...